$BBh(B9$B4,Bh(B1$B9f(B $BL\

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$B%Y%-JQ49$NJQ49<\EY$NITJQ2=D4@0!!_@:j=S8w!&8eF#>;;J(B

$BN%;6JQ?t%i%s%@%`;~7ONs$N3NN(M}O@!!6aF#K'O/!&@nIt!!7r(B

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$B3X2q3hF05-;v(B

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$BCN<1H/8+K!$K$h$kC5:wE*%G!<%?2r@O(B
$BM:;3??5](B,$B2,ED!!9'(B, $BM{!!5.Jv(B:$B4X@>3X1!Bg3X(B $B>pJs=hM}8&5f%;%s%?!<(B
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$B5"GZ$H8zN(E*$JMxMQK!$N2rL@$rL\E*$H$7$?(B. $BNc$H$7$F(B, $B>/$J$$@bL@JQ?t$J$,$iJ#;($J%G!<%?J,I[$r<($9=[4D4o7O8!?G%G!<%?$H(B, $BHs>o$KB??t$NJQ?t$K$h$j5-=R$5$l$k@8M}3h@-J*e$2$F2r@O$r9T$C$?(B. $B$=$N7k2L(B, $BDL>o$NB?JQNL2r@OK!$G$O8+F($7$,$A$J6I=jE*$J%G!<%?J,I[$NFCD'$r$h$/GD0.$G$-$k$3$H$,H=L@$7$?(B. $B$^$?(B, $B8zN(E*$K2r@O$r?J$a$k$?$a$N%Q%i%a!<%?$N@_DjK!$rL@$i$+$K$9$k$3$H$,$G$-$?(B.
keyword{Medical diagnosis, Structure activity relationship, IDIS, Datalogic/R}

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$B%;%_%Q%i%a%H%j%C%/2s5"LdBj$K$*$1$k(B $B%9%W%i%$%sJ?3j2=(B
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$B%N%s%Q%i%a%H%j%C%/2s5"$N(B1$B$D$NJ}K!(B, $B%9%W%i%$%sJ?3j2=$K$D$$$FO@$:$k(B. $B:G=i$K(B1$Bl9g$K(B, $B%;%_%Q%i%a%H%j%C%/2s5"%b%G%k$rO@$8$k(B. $B$3$N%b%G%k$O(B1$B$D(B($B$^$?$O$=$l0J>e(B)$B$NJQ?t$K$D$$$F$O%N%s%Q%i%a%H%j%C%/4X?t$r(B, $BB>$NJQ?t$K$D$$$F$O@~7A4X?t$r$"$F$O$a(B, $B$=$l$i$N2CK!@-$r2>Dj$7$?$b$N$G$"$k(B. $BN>J}$N@.J,$N?dDjNL$rF3=P$7(B, $BJ;$;$FG@CO$G$O%;%_%Q%i%a%H%j%C%/2s5"$N?dDjNL$K4X$9$kA26aE*@-.$5$/$F$b$"$kDxEYJP$j$rM^$($k(IJ$B$r$b$A(B, $BB>J}(B2$BCJ3,%9%W%i%$%sJ?3j2=$K$h$k?dDjNL$OI8K\%5%$%:$,Bg$-$$$H$-$N$_8z2L$,$"$k$3$H$,$o$+$k(B.
keyword{Nonparametric regression, Semiparametric regression model, Spline smoothing, Penalized least squares, Cross-validation}

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$B%Y%-JQ49$NJQ49<\EY$NITJQ2=D4@0(B
$B_@:j(B $B=S8w(B:$B%U%!%$%6!<@=Lt3t<02q $B8eF#>;;J(B:$BBg:eBg3XBg3X1!4pAC9)3X8&5f2J>pJs?tM}7O@l96(B

Box & Cox(1964)$B$NDs0F$7$?%Y%-JQ49$O0lHL$K(B, $B4QB,CM$NJQ49$KH<$&<\EY$NITJQ@-$r$b$?$J$$(B. $B$=$N$?$a$K(B, $B%Y%-JQ49$NA08e$G4QB,CM$N<\EY$K0MB8$9$kNL$G$b$C$FJQ498e$NE}7WE*$J=hM}$r?J$a$k$3$H$O0UL#$r$J$5$J$$(B. $B$3$N$H$-(B, $B%Y%-JQ49%Q%i%a!<%?$K0MB8$7$?<\EY8z2L$r$H$j=|$/$?$a$K(B, $BJQ49$N(B Jacobian$B$N(B n$B>h:,$GJQ498x<0$r;v8eE*$KD4@0$7$?!VD4@0%Y%-JQ49!W$rE,MQ$9$k$3$H$,9M$($i$l$k(B. $BK\O@J8$G$O(B, $B4QB,CM$N=89g$NJ,I[$r2A$7$?(B. $B$=$N7k2L$+$i(B, $BD4@0%Y%-JQ49$G$OD4@0$r;\$5$J$$DL>o$N%Y%-JQ49$KHf$Y$F%Y%-JQ49%Q%i%a!<%?$K0MB8$7$?<\EY8z2L$,$H$j=|$+$l$k$3$H$,<(:6$5$l$?(B.
keyword{Ordinary power transformation, Normalizing power transformation, Jacobian of transformation, Relative change rate}

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$BN%;6JQ?t%i%s%@%`;~7ONs$N3NN(M}O@(B ---$B0LAj<~4|$H$=$N3NN((B ---
$B6aF#K'O/(B:$B@n:j0e2JBg3X(B $BJ*M}65<<(B
$B@nIt!!7r(B:$B2,;3Bg3X(B $BM}3XIt(B ($B8=(B $BDE;39)6H9bEy@lLg3X9;(B $BJ*M}(B)

$B0lMM$J=P8=3NN($r;}$DL55,B'$JN%;6JQ?t$NL58B7ONs$K$D$$$F(B, $BNY$j9g$&6KBgCM(B($B$"$k$$$O6K>.CM(B)$B4V$N?tNs$ND9$5$G$"$k0LAj<~4|$N3NN($rN%;6CM(B r$B$N4X?t$H$7$FF3=P$9$k(B. $B0LAj<~4|$NJ?6QCM(B, $B308+<~4|$O(B 3+3/(2r-1) $B$GM?$($i$l$k(B. $B>/?t$N5<;wMp?tNs$d0lHL$N?tCM keyword{Gross period, Random number sequence, Discrete random numbers}

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$B7WNLJ88%3X$NNr;K$H2]Bj(B
$BB<>e@,>!(B:$BE}7W?tM}8&5f=j$*$h$SAm9g8&5fBg3X1!Bg3X(B

$B6aG/$N%Q%=%3%s$r$O$8$a$H$9$k%G!<%?=hM}5!4o$NH/C#$H(B, $BB?JQNL2r@O$J$I$rCf?4$H$9$kE}7WR2p$7(B, $B keyword{Authorship problem, Length of sentence, Words frequency}

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SAS$B$K$h$k0eLt8&5f$NNc?t@_7W(B -- $B%7%_%e%l!<%7%g%s$K$h$k8!=PNO$NI>2A(B --
$BIMEDCN5WGO(B:$BEl5~Bg3X0e3XItLt:^1V3X65<<(B
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$B%5%$%:$N@_7W$G$"$k(B. $B4JC1$J(B2$BI8K\LdBj$K$D$$$F$O(B, $B%5%s%W%k!&%5%$%:$N7W;;8x<0$,CN$i$l$F$$$k(B. $B$H$3$m$,/J#;($JLdBj$K$D$$$F$O(B, $B%5%s%W%k!&%5%$%:$N7W;;8x<0$O==J,$K$O@0Hw$5$l$F$$$J$$(B. $BK\9F$G$O$3$N$h$&$K2r@OE*$J%"%W%m!<%A$GBP1~$,Fq$7$$B?72$NNc?t@_7W$NLdBj$K$D$$$F(B, SAS$B$NMp?t4X?t$H(B, MULTTEST$B%W%m%7%8%c$rMQ$$$F(B, $B%7%_%e%l!<%7%g%s$K$h$C$F%5%s%W%k%5%$%:@_7W$r9T$&%"%W%m!<%A$r>R2p$9$k(B.

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$B3F9f$N>R2p$XLa$k(B